Cutaneous ageing is due to physical agents like solar radiation, and climatic factors…as well as to internal factors related to the natural senescence of cutaneous tissue.
It appears through the atrophy of the skin and a qualitative and quantitative deterioration of derm.
It has two principal components :
- The fundamental substance, glycosaminoglycans (structural glycoproteins) from which the most significant are hyaluronic acid, chondroïtine and chrondroïtine-sulphate.
- Fibrous proteins: collagen gives the skin its resistance, Elastin (elastic fibers) ensures its’ elasticity and tonicity.
These two elements are produced by the fibroblasts, cells largely represented in the skin.
Alterations of Derm Due to Ageing
Apart from the pathological states (arteriosclerosis, diabetes), age leads to a rarefaction, then a disappearance of elastic fibres. For elastin, reduction and deterioration (fragmentation) of fibres appears. All that leads to the appearance of lines ( ‘heliodermy’ ) and more marked and durable wrinkles, dependent on a drop in tonicity and cutaneous elasticity ( ‘chronodermy’ ).
The Kappa-Elastine Parade
Absence of elastin in derm can it be compensated by an external contribution. Elastin is obtained from natural issue; it is a non soluble molecule with a very high molecular weight. Its controlled hydrolysis in small fragments (peptides) reconstitutes the soluble molecule Elastin and allows the preparation in the derm. On the other hand, if fragmentation is total, the obtained product lost the characteristics of the original molecule elastin and is no longer matter of amino acids .
This original and effective process is proposed to us by SOLUBLE KAPPA-ELASTINE or ELASTIN PEPTIDES.
As shown in the scientific works, its partial hydrolysis allows the passage transepidermic passage and the progressive reconstitution of ‘‘a YOUTH CAPITAL’‘ by fixing on the aging elastin fibers. Its presence also stimulates the fibroblasts for the endogenous production of elastin and neocollagen.
In conclusion, we can say that the discovery of Kappa-Elastin represents a real progress in medical cosmetics because it applies a complementary process to the rejuvenation of skin in a soft and progressive form, appreciated by the patients.
PHARMACOLOGICAL STUDIES OF ELASTIN PEPTIDES (Kappa-Elastin) Blood Clearance, percutaneous penetration and tissue distribution.
MENASCHE M, MP JACOB, (1) G. GODEAU (2), A.M ROBERT (2), L. ROBERT (2), Biol, 1981, 29, n°9, 548-554
1) INSERM U 86, Foundation A. of Rothschild, 29 rue Manin, 75019 PARIS (FRANCE)
2) Laboratoire de Biochimie du Tissu conjonctif ( GR CNRS N° 40), Faculté de Médecine, Université Paris-Val de Marne, 8 rue du Général Sarrail, 94010 CRETEIL Cedex ( France)
The soluble Elastin Peptides obtained by partial hydrolysis of ligament (Kappa-Elastin) were marked in vitro. Marked Kappa-Elastin was managed by intravenous and percutaneous way, its elimination and its distribution in the body given. Kappa-Elastin is quickly eliminated primarily by the kidneys. The Elastin Peptides managed by percutaneous way penetrate in derm. The resorption though the skin is a slow process.
Histochemical studies made on the skin during 4 weeks showed an increase in the material taking the coloring of elastin. These histochemical results confirm the penetration of elastin peptides in derm, their association with collagen fibers and also their action on the cellular activity of derm.